{"id":21,"date":"2005-07-04T00:00:00","date_gmt":"2005-07-04T00:00:00","guid":{"rendered":"http:\/\/elegans.uky.edu\/blog\/?p=21"},"modified":"2005-07-04T00:00:00","modified_gmt":"2005-07-04T00:00:00","slug":"tumors-in-animals","status":"publish","type":"post","link":"http:\/\/jimlund.org\/blog\/?p=21","title":{"rendered":"Tumors in animals"},"content":{"rendered":"<p>My youngest brother has been reading \u00e2\u20ac\u0153healthy eating\u00e2\u20ac\u009d books, and was telling me that wild animals don\u00e2\u20ac\u2122t get cancer. He wasn\u00e2\u20ac\u2122t content with my correction and wanted some evidence. Fair enough. Looking around online, I found a few references and was reminded of the Laetrile nonsense.<\/p>\n<p>Laetrile was a quack cancer cure popular in the 70\u00e2\u20ac\u2122s. The tout was that sharks don\u00e2\u20ac\u2122t get cancer, and that taking pills made from ground up shark cartilage would cure cancer. This paragraph give a summary of the Laetrile cure fad:<\/p>\n<blockquote><p><a href=\"http:\/\/www.smm.org\/boghopper\/sciencebriefs.html\">Crude shark cartilage extract is not a cure for cancer in humans<\/a><br \/>\nPromotion of cartilage extracts from sharks has had two negative outcomes: a decline in shark populations, and a diversion of patients from effective cancer treatment. The argument has been that sharks don\u00e2\u20ac\u2122t get cancer. However, both malignant and benign neoplasms of sharks and their relatives were described by Gary Ostrander and associates at Johns Hopkins University (Maryland), Penn State College of Medicine, and <a href=\"http:\/\/www.pathology-registry.org\/index_1.asp\">Registry of Tumors in Lower Animals (Virginia)<\/a>. So far there is no evidence to support the use of crude cartilage nor any cartilage extract to reach and eradicate cancer cells. The authors see the use of shark cartilage extracts as another example of pseudoscience used in decision making where the facts are not considered. (Cancer Research 64: 8485-8491, 2004)<\/p><\/blockquote>\n<p>The reference to the Registry of Tumors in Lower Animals sounds intriguing so I looked it up. The collection is searchable online after registering, and I\u00e2\u20ac\u2122ve included a link. The Registry includes many cases of cancer in wild animals.<\/p>\n<p>Looking around a bit more, I find someone else has considerately done a search of the literature, and posted abstracts. I\u00e2\u20ac\u2122ve includes them below (lost track of the original source). These reports come from journals indexed by <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=PubMed\">Pubmed<\/a> which indexes biomedical journals, so papers in ecological or field biology journals would be missed. As you can see, there are many reports describing cancer in wild animals. The list is long, but skimming shows that tumors in wild animals have been observed many times.<\/p>\n<p>Next up, I\u00e2\u20ac\u2122ll look into the notion you\u00e2\u20ac\u2122ve gotten that microwaving your food makes it dangerous to eat.<\/p>\n<blockquote><p>\n    Cesk Patol 1996 May;32(2):78-83<\/p>\n<p>    [Tumors in wildlife].<\/p>\n<p>    [Article in Czech]<\/p>\n<p>    Karpenko A, Bukovjan K.<\/p>\n<p>    Oddeleni patologie SZZ, Benesov u Prahy.<\/p>\n<p>    Wild animal tumours have not been much studied yet. Authors found six<br \/>\n    mostly benign cases in Czech Republic in checking hunts between the years<br \/>\n    1988 and 1993: Mature differentiated ovarian teratoma and apocrine skin<br \/>\n    adenoma in field hare, intraductal mammary papillomatosis in a roe,<br \/>\n    complex odontoma and pleomorphic mammary carcinoma (single malignancy in<br \/>\n    the group) in fox. A soft tissue tumour in a fallow-buck\u00e2\u20ac\u2122s neck could not<br \/>\n    be histogenetically classified. A high structural equivalence of animal<br \/>\n    and human tumours allows using ICD-O classification as a whole.<\/p>\n<p>    PMID: 9560906 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Vet Med Sci 1997 Aug;59(8):703-6<\/p>\n<p>    Spontaneous gastric carcinoid tumors in the striped field mouse (Apodemus<br \/>\n    agrarius).<\/p>\n<p>    Oh SW, Chae C, Jang D.<\/p>\n<p>    Department of Veterinary Pathology, College of Veterinary Medicine, Seoul<br \/>\n    National University, Suwon, Kyounggi-Do, Republic of Korea.<\/p>\n<p>    Gastric carcinoid tumors were found in seven of 135 striped field mice<br \/>\n    (Apodemus agrarius) by routine histopathologic examination. All these<br \/>\n    carcinoids occurred in mature striped field mice aged 72-100 weeks. Six<br \/>\n    animals were females and only one was male. Only two of seven tumors were<br \/>\n    detectable by gross examination. Grossly, tumors were located in the<br \/>\n    fundus of the glandular stomach. All seven tumors were microscopically<br \/>\n    single in the stomach and two mice exhibited extragastric metastasis.<br \/>\n    Tumors from all the mice were characterized by densely packed sheets of<br \/>\n    round to polygonal cells, subdivided into packets by a fine fibrovascular<br \/>\n    stroma. The cytoplasm of all tumor cells from all the mice contained<br \/>\n    argyrophil granules when stained by Grimelius and Sevier-Munger silver<br \/>\n    procedures. All seven mice with gastric carcinoids exhibited positive<br \/>\n    immunoreactivity to neuron specific enolase. Psammoma bodies,<br \/>\n    concentrically laminated microcalcification, were characteristic findings<br \/>\n    in gastric carcinoids from five mice. There were also a concomitant and<br \/>\n    independent hepatocellular adenoma in one case and hepatocellular<br \/>\n    carcinoma in two cases. The present cases provide the first description<br \/>\n    of spontaneous gastric carcinoid tumors in the striped field mice.<\/p>\n<p>    PMID: 9300368 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Leukemia 1997 Apr;11 Suppl 3:170-1<\/p>\n<p>    Plasmacytoid leukemia of chinook salmon.<\/p>\n<p>    Kent ML, Eaton WD, Casey JW.<\/p>\n<p>    Department of Fisheries and Oceans, Pacific Biological Station, Nanaimo,<br \/>\n    B.C., Canada.<\/p>\n<p>    Plasmacytoid leukemia is a common disease of seawater pen-reared chinook<br \/>\n    salmon (Oncorhynchus tshawytscha) in British Columbia, Canada, but has<br \/>\n    also been detected in wild salmon, in freshwater-reared salmon in United<br \/>\n    States, and in salmon from netpens in Chile. The disease can be<br \/>\n    transmitted under laboratory conditions, and is associated with a<br \/>\n    retrovirus, the salmon leukemia virus. However, the proliferating<br \/>\n    plasmablasts are often infected with the microsporean Enterocytozoon<br \/>\n    salmonis, which may be an important co-factor in the disease.<\/p>\n<p>    PMID: 9209333 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Pathol Int 1996 Dec;46(12):919-32<\/p>\n<p>    Mouse mammary tumor virus and mammary tumorigenesis in wild mice.<\/p>\n<p>    Imai S.<\/p>\n<p>    Nara Prefectural Institute of Public Health, Japan.<\/p>\n<p>    The current knowledge of the distribution of the mouse mammary tumor<br \/>\n    virus (MMTV) proviral genomes and the mechanism of mammary tumorigenesis<br \/>\n    by MMTV in mice, with the main emphasis on Asian feral mice, is reviewed.<br \/>\n    The relevant earlier discoveries on the mode of MMTV transmission are<br \/>\n    summarized to provide an outline of the biology of MMTV. Finally, the<br \/>\n    viral etiology of human breast cancer will be discussed.<\/p>\n<p>    Publication Types:<br \/>\n    Review<br \/>\n    Review, academic<\/p>\n<p>    PMID: 9110343 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Adv Neurol 1991;56:473-9<\/p>\n<p>    Retroviral leukemia and lower motor neuron disease in wild mice: natural<br \/>\n    history, pathogenesis, and genetic resistance.<\/p>\n<p>    Gardner MB.<\/p>\n<p>    Department of Pathology, School of Medicine, University of California, Davis<br \/>\n    95616.<\/p>\n<p>    Publication Types:<br \/>\n    Review<br \/>\n    Review, tutorial<\/p>\n<p>    PMID: 1649545 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Wildl Dis 1985 Oct;21(4):386-90<\/p>\n<p>    Diseases diagnosed in wild turkeys (Meleagris gallopavo) of the southeastern<br \/>\n    United States.<\/p>\n<p>    Davidson WR, Nettles VF, Couvillion CE, Howerth EW.<\/p>\n<p>    Diagnostic findings are presented on 139 sick or dead wild turkeys<br \/>\n    examined during the period 1972 through 1984. Turkeys originated from<br \/>\n    eight southeastern states (Alabama, Arkansas, Florida, Georgia, South<br \/>\n    Carolina, Tennessee, Virginia, West Virginia) and included 31 turkeys<br \/>\n    categorized as capture-related mortalities and 108 turkeys categorized as<br \/>\n    natural mortalities. Frequent diagnoses (greater than or equal to 10% of<br \/>\n    case accessions) in the natural mortality group were trauma, avian pox,<br \/>\n    and histomoniasis. Less frequent diagnoses (less than or equal to 4% of<br \/>\n    case accessions) included malnutrition\/environmental stress syndrome,<br \/>\n    coligranuloma-like condition, crop impaction, bumblefoot, organophosphate<br \/>\n    toxicosis, infectious sinusitis, a lympho-proliferative disease,<br \/>\n    salmonellosis, aspergillosis, toxoplasmosis, crop trichomoniasis, and<br \/>\n    melorheostosis.<\/p>\n<p>    PMID: 4078973 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Acta Vet Scand 1985;26(1):61-71<\/p>\n<p>    Leukaemic neoplasia in free-living mammals in Denmark.<\/p>\n<p>    Elvestad K, Henriques UV.<\/p>\n<p>    PMID: 3839967 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Int J Cancer 1981 Aug 15;28(2):241-7<\/p>\n<p>    Natural killer cell activity in a population of leukemia-prone wild mice<br \/>\n    (Mus musculus).<\/p>\n<p>    Scott JL, Pal BK, Rasheed S, Gardner MB.<\/p>\n<p>    Natural cell-mediated cytotoxicity against YAC-I targets was measured in<br \/>\n    splenocytes from leukemia-prone wild mice trapped near Lake Casitas (LC)<br \/>\n    in southern California. Cytotoxicity was mediated by cells that were<br \/>\n    non-adherent to nylon wool, non-phagocytic and resistant to thy-1.2<br \/>\n    antiserum plus complement. Natural MuLV viremia in LC mice did not impair<br \/>\n    splenic cytotoxicity against TAC-I target cells, Cells infected with<br \/>\n    amphotropic and ecotropic MuLV of wild mouse origin were not appreciably<br \/>\n    lysed by LC splenic effectors. Although variable levels of cytotoxicity<br \/>\n    were detected against TAC-1 by normal spleen cells, consistently low<br \/>\n    levels of cytotoxicity against allogenic LC lymphoma, sarcoma and<br \/>\n    carcinoma targets were found using the same splenocytes. These results<br \/>\n    indicate that LC mice possess splenocytes with the characteristics of<br \/>\n    natural killer (NK) cells as defined in inbred mice. The resistance of<br \/>\n    LC-derived targets to lysis by LC NK cells suggests that NK cells may not<br \/>\n    be involved in natural tumor immunosurveillance or that the development<br \/>\n    of spontaneous tumors may involve escape from NK-mediated effector<br \/>\n    mechanisms.<\/p>\n<p>    PMID: 6274813 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    Vet Pathol 1977 Nov;14(6):539-46<\/p>\n<p>    Gynecologic pathology in the rhesus monkey (Macaca mulatta). II. Findings in<br \/>\n    laboratory and free-ranging monkeys.<\/p>\n<p>    DiGiacomo RF.<\/p>\n<p>    The most prevalent findings in reproductive tracts of 38 laboratory and<br \/>\n    17 free-ranging Rhesus female monkeys were vaginitis, cervicitis,<br \/>\n    metritis, pelvic endometriosis and uterine adenomyosis. Several monkeys<br \/>\n    had cervical dysplasia and one had a serous cystadenoma. The findings in<br \/>\n    the two groups were similar although prevalence for several diseases<br \/>\n    differed. There was a significant relationship between the occurrence of<br \/>\n    vaginitis, metritis, adenomyosis and endometriosis and gravidity, time<br \/>\n    since last pregnancy, number of matings, hysterotomies, reproductive<br \/>\n    ability and reproductive status.<\/p>\n<p>    PMID: 412291 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Wildl Dis 1999 Oct;35(4):804-7<\/p>\n<p>    Relating tumor score to hematology in green turtles with<br \/>\n    fibropapillomatosis in Hawaii.<\/p>\n<p>    Work TM, Balazs GH.<\/p>\n<p>    U.S. Geological Survey, Biological Resource Division, National Wildlife<br \/>\n    Health Center, Honolulu Field Station, Hawaii 96850, USA.<br \/>\n    thierry_work@usgs.gov<\/p>\n<p>    The relationship between hematologic status and severity of tumor<br \/>\n    affliction in green turtles (Chelonia mydas) with fibropapillomatosis<br \/>\n    (FP) was examined. During 1 wk periods in July 1997 and July 1998, we<br \/>\n    bled 108 free-ranging green turtles from Pala\u00e2\u20ac\u2122au (Molokai, Hawaii, USA)<br \/>\n    where FP is endemic. Blood was analyzed for hematocrit, estimated total<br \/>\n    solids, total white blood cell (WBC) count and differential WBC count.<br \/>\n    Each turtle was assigned a subjective tumor score ranging from 0 (no<br \/>\n    visible external tumors) to 3 (heavily tumored) that indicated the<br \/>\n    severity of FP. There was a progressive increase in monocytes and a<br \/>\n    decrease in all other hematologic parameters except heterophils and total<br \/>\n    numbers of white blood cells as tumor score increased. These data<br \/>\n    indicate that tumor score can relate to physiologic status of green<br \/>\n    turtles afflicted with FP, and that tumor score is a useful field monitor<br \/>\n    of severity of FP in this species.<\/p>\n<p>    PMID: 10574546 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Wildl Dis 1999 Oct;35(4):753-62<\/p>\n<p>    Descriptive epidemiology of roe deer mortality in Sweden.<\/p>\n<p>    Aguirre AA, Brojer C, Morner T.<\/p>\n<p>    Department of Wildlife, The National Veterinary Institute, Uppsala, Sweden.<br \/>\n    aguirre@wpti.org<\/p>\n<p>    A retrospective epidemiologic study was conducted to examine causes of<br \/>\n    mortality of 985 wild roe deer (Capreolus capreolus) submitted to the<br \/>\n    National Veterinary Institute (SVA; Uppsala, Sweden) from January 1986 to<br \/>\n    December 1995. Age, sex, body condition, and geographic distribution as<br \/>\n    related to disease conditions are reported herein. The most common causes<br \/>\n    of mortality in roe deer were trauma (19%), winter starvation (18%),<br \/>\n    gastritis\/enteritis (15%), bacterial infections (11%), parasitic<br \/>\n    infection (11%), systemic diseases (11%), neoplasia (2%), congenital<br \/>\n    disorders (1%), and miscellaneous causes (6%). Cause of death was not<br \/>\n    determined in 6% of the cases. The distribution of causes of death<br \/>\n    reported in this study differ from previous works in Sweden in that<br \/>\n    infectious and parasitic diseases were more common than winter<br \/>\n    starvation. The pathologic findings in studies like this do not<br \/>\n    necessarily represent what is occurring in the natural environment, but<br \/>\n    they do provide a good indication of distribution of diseases over time<br \/>\n    as well as age and sex structure in relation to disease conditions.<br \/>\n    Further research and more detailed studies are in progress to better<br \/>\n    understand specific mortality factors as well as etiologies of certain<br \/>\n    described diseases in roe deer in Sweden.<\/p>\n<p>    PMID: 10574535 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Zoo Wildl Med 1999 Mar;30(1):165-9<\/p>\n<p>    Herpesvirus-associated papillomas in koi carp (Cyprinus carpio).<\/p>\n<p>    Calle PP, McNamara T, Kress Y.<\/p>\n<p>    Wildlife Health Sciences, Wildlife Conservation Society, Bronx, New York<br \/>\n    10460-1099, USA.<\/p>\n<p>    From January through November 1994, 32% (7\/22) of koi carp (Cyprinus<br \/>\n    carpio) maintained in indoor aquariums developed proliferative cutaneous<br \/>\n    lesions that consisted of single to multiple 2-10-mm whitish to pink<br \/>\n    fleshy masses usually associated with fin rays. Although scaleless koi<br \/>\n    were more commonly affected (3\/6) than were normally scaled koi (4\/16),<br \/>\n    the difference in incidence rates was not significant (chi2 text, P ><br \/>\n    0.05). Lesions typically resolved spontaneously in 1-3 wk, occasionally<br \/>\n    persisted for >3 mo, and recurred in several fish after 2-5 mo. Fish were<br \/>\n    otherwise asymptomatic. Wet mount preparations from lesions were densely<br \/>\n    cellular and consisted of hyperplastic epidermal cells of normal<br \/>\n    morphology without parasites or inflammatory cells. Histologically,<br \/>\n    biopsies were consistent with papillomas and were characterized by a<br \/>\n    marked benign epidermal hyperplasia without inclusion bodies or<br \/>\n    inflammatory infiltrate. Transmission electron microscopic examination<br \/>\n    revealed intranuclear and intracytoplasmic herpesvirus virions. Virus<br \/>\n    isolation attempts were unsuccessful.<\/p>\n<p>    PMID: 10367660 [PubMed &#8211; indexed for MEDLINE]<\/p>\n<p>    J Wildl Dis 1999 Apr;35(2):392-4<\/p>\n<p>    Adenocarcinoma of the mammary gland in a red fox from Austria.<\/p>\n<p>    Janovsky M, Steineck T.<\/p>\n<p>    Research Institute of Wildlife Ecology, University of Veterinary Medicine,<br \/>\n    Vienna, Austria.<\/p>\n<p>    A mammary gland adenocarcinoma was diagnosed in an adult red fox (Vulpes<br \/>\n    vulpes) which was shot in Austria in August 1995. Metastases were found<br \/>\n    in the kidneys and liver. This is the first reported case of an<br \/>\n    adenocarcinoma in a fox, and lack of mammary gland carcinoma in this<br \/>\n    species may be age related.<\/p>\n<p>    PMID: 10231770 [PubMed &#8211; indexed for MEDLINE]\n<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>My youngest brother has been reading \u00e2\u20ac\u0153healthy eating\u00e2\u20ac\u009d books, and was telling me that wild animals don\u00e2\u20ac\u2122t get cancer. He wasn\u00e2\u20ac\u2122t content with my correction and wanted some evidence. Fair enough. Looking around online, I found a few references and was reminded of the Laetrile nonsense. Laetrile was a quack cancer cure popular in the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,6,19],"tags":[],"class_list":["post-21","post","type-post","status-publish","format-standard","hentry","category-aging","category-general","category-sci-general"],"_links":{"self":[{"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21"}],"version-history":[{"count":0,"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=\/wp\/v2\/posts\/21\/revisions"}],"wp:attachment":[{"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/jimlund.org\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}