Great article at the Pathogens: Genes and Genomes blog.
The technology generation after next-gen (next-next-gen?) is getting close!
And here’s an article from 2009, the first using single molecule sequencing to sequence a human genome. Helicos short read tech was used, and the reagent cost was $50k. Pushkarev, Neff, and Quake.
The Li and Wang News and Views summary of the Pushkarev article has a good overview of next-gen sequencing.