Cavalcade of Mammals

A new therapeutic approach developed by McMaster researchers could help prevent brain cancer. Targets inosine monophosphate dehydrogenase 2 (IMPDH2), one of two enzymes researchers say is “vital” to metastases.

Decline of Ph.D. Admissions Could Imperil a ‘Generation of New Talent’. Some of the nation’s top research universities are shrinking doctoral programs because of uncertain federal funding.
25% decline in PhD science students over the last two years.

New Theory of Smallest Human: Not a Hunter, But Eater of Lizard Leftovers.
Homo floresiensis had been on Flores for at least 700,000 years and apparently over 1.2 million, did not have fire.
Homo luzonensis: A small, ancient human species from the Philippines.
Homo luzonensis, discovered on the island of Luzon in the Philippines. Just 13 fossils of this ancient human species have been found.

Injections of ‘MOTS-c’ Can Make You Live Longer. If You Are a Mouse. Discovery may become a springboard for developing drugs with a potential effect on aging and longevity.
Results were unclear: MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Why ‘The Ocean Cleanup’ Hasn’t Solved the Plastic Pollution Crisis
The Ocean Cleanup: 117.3 million pounds of waste at $72 million
Ocean Conservancy’s International Coastal Cleanup: 400 million pounds waste at $6 million (volunteers at beaches)

The end of the genetic paradigm of cancer. The growing awareness of epigenetic changes in cancer.

When We Fight, We Win: Why I Am Suing Northwestern University—and the US Government. Steven W. Thrasher on the Fight For Academic Freedom

Jet Set Radio game
MindRover game

Roger Lootine, RIP. I remember his cartoons at Fremd, he continued with it and was a cartoonist. Link to info about his career in MN.

qilin (English: /tʃiˈlɪn/ chee-LIN) is a legendary hooved chimerical creature that appears in Chinese mythology

The greatest college application essay ever

Mount Ida hike in RMNP.

What is Tenebrescence? (All about Hackmanite – Hint: it’s not fluorescence)

How To Talk to Anyone About OMB-2026-0034

AAAS Statement on OMB Rule Politicizing Federal Grantmaking

Bullseye Glass Portland, Oregon: learn fused glass online. for free.

Covid vaccine linked to broad protections against heart conditions, study finds. A new study finds the vaccine was linked with nearly 40 percent lower risk of events like heart attack and stroke
2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans

The Con-Artist Physics of “Ocean’s Eleven”

Viewpoint: COVID lab leak? Misguided backers of the lab leak theory refuse to give up. by Angela Rasmussen

“They Would Never Use the Death Star on Us”: Alderaan Residents Reflect on Their Support for the Empire as a Large Imperial Installation Enters the System by Jack Loftus

How the Bird Eye Was Pushed to an Evolutionary Extreme. The bird retina is one of the most energetically expensive tissues in the animal kingdom, yet it doesn’t use the energy advantage of oxygen. New research finally explains how this is possible.

The seed oil panic is hurting my cardiac patients. by Cole Hanson

Bluebird by Ciel Pierlot. The story follows Rig as she embarks on a journey across the galaxy to save her estranged sister from her former faction – who are trying to blackmail her into returning what she stole from them.

The new moonshot by Jacinta Bowler, Joshua Byrd and Teresa Tan.

The National Park Service race to rewrite history becomes a slog by Heather Richards
“The sheer volume of park signs, panels and museum exhibits flagged by park rangers because they mentioned topics like slavery, climate change or violence against Native Americans overwhelmed the Trump administration from the beginning, said three people familiar with the process used to evaluate potential changes, granted anonymity because they feared retribution.”

The Pink Park Ranger Takedown: CCC vs White Supremacy

Unpublished Games Network (Unpub). We support the game design and development community by organizing events intended to help designers receive public playtests and feedback, and connect with other tabletop gaming industry folks. These events are open to anyone who wishes to bring their game to the table.

Google Has a Secret Reference Desk. Here’s How to Use It.
climate AROUND(3) policy
intitle: “index of” inurl:gov
“can anyone recommend”
“the * of artificial intelligence”

The NIH Restructuring Congress Rejected Is Happening Anyway by Elizabeth Ginexi

Selling Oppression to Gen Z Women by Jessica Valenti and Kylie Cheung

Limitations of serial cloning in mammals.
“…we continued serial cloning for 20 years from a single donor mouse. These re-cloned mice appeared normal and had normal lifespans, but large structural and lethal mutations accumulated in their DNA with each generation. The birth rate of serial cloning began to decline from the 27th generation, and the 58th generation was the last.”

Kindle e-reader models
Kindle root / dashboard project
Kindle jailbreaking

Windsurf Launches SWE-1: AI Models Built for the Entire Software Engineering Process

Landmark NHS-Galleri Trial Demonstrates a Substantial Reduction in Stage IV Cancer Diagnoses, Increased Stage I and II Detection of Deadly Cancers, and Four-Fold Higher Cancer Detection Rate

PCSK9 inhibition: A game changer in cholesterol management, PSCK9.
PSCK9 / heart disease discovery paper

Early trials of the prostate cancer drug VIR-5500 showed it shrinking tumours in some patients

Everyone is stealing TV. Fed up with increasing subscription prices, viewers embrace rogue streaming boxes.

Rare, dangerous side effects of some COVID-19 vaccines explained. “Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people

Cistercian numerals

Prison guards discussed cover-up of Epstein’s death, inmate tells FBI. by Julie K. Brown

Drugs Would Be Cheap but for Patents That Make Them Expensive by Dean Baker

DOJ nopes out of Ticketmaster antitrust suit

Illumina Constellation Becomes TruPath Genome. $395 / genome, 30X with long read type connectivity information.

The Women Leaving the New Right

Chicago did it, in 2025 we had the fewest murders recorded since 1965–416 in 2025, 395 in 1965!

J6ers: Where Are They Now? Catching up with notorious insurrection offenders a year after Trump’s pardon spree.

JD Vance Roasted After Comparing Trump Economy to ‘Titanic’

Nature article on cuts to Science funding under the Trump administration. Cuts of 25% to 35% this year. Fewer new grants funded. Science agency staff cut 20%. International students down 17%. Nature analysis.

Trump’s acting cyber chief uploaded sensitive files into a public version of ChatGPT

User Clip: Trumps insane mental asylum rant

If He Builds It, Tear It Down. Pendulums must swing. by Hamilton Nolan

Illumina: Introducing constellation mapped read technology

Monitor network traffic to web server:
tshark ‘tcp port 80 and (((ip[2:2] – ((ip[0]&0xf)<<2)) – ((tcp[12]&0xf0)>>2)) != 0)’

He made beer that’s also a vaccine. Now controversy is brewing. A scientist’s unconventional project illustrates many challenges in developing new vaccines. by Tina Hesman Saey

Golf Carts w/missing wheels: Rebutting Sen. Lankford’s CNN Appearance, Part 2

Within five years, anything above an entry-level bike will require batteries — and I don’t like it. Bikes shouldn’t need batteries to work: a stance against electronic shifting’s ubiquity. by Michael Venutolo-Mantovani

Setting up web commerce / shopping cart on a WordPress site: woocommerce module & oceawp theme.

James Watson, dead at 97, was a scientific legend and a pariah among his peers. He co-discovered DNA’s structure but later engaged in rank racism and sexism. by Sharon Begley

“From today until 2030 big tech firms will spend $5trn on infrastructure to supply AI services. To make those investments worthwhile, they will need on the order of $650bn a year in AI revenues, according to JPMorgan Chase, a bank, up from about $50bn a year today.” link

How to Make Repeat Patterns: A Guide for Designers, Architects and Artists. by Paul Jackson.
Designing tessellations : the secrets of interlocking patterns. by Jinny Beyer.

Cory Doctorow on the AI bubble
AI as Normal Technology. An alternative to the vision of AI as a potential superintelligence

Lessons from a Red Scare. The American people are capable of turning the tide against repression. by David R. Lurie

Pi with the Major system:

Mad, rat, lip, nacho, llama, lava, pack, puma, gnome, fire
mad -> 31 rat -> 41 lip -> 59 nacho -> 26 llama -> 53 lava -> 58 pack -> 97 puma -> 93 gnome -> 23 fire -> 84
100 digits of pi:

perl -e 'use Math::BigFloat "bpi";print "pi: ",bpi(101),"\n";'

3.1415926535897932384626433832795028841971693993751058209749445923078164062862089986280348253421170680

1. “My Turtle Pancha will, my love pick up my new mover,Ginger”
2. “my movie monkey plays in, a favorite bucket
3. ship my puppy michael to sullivan’s backrubber
4. a really open music video cheers jenny F. jones
5. have a baby fish knife so marvin will marinate the goosechick

Using word length:
Pie, I wish I could remember pi,
“Eureka!” cried the great inventor,
Christmas pudding, Christmas pie,
Is the problem’s very center.

Algorithms for making interesting organic simulations

Scientists just cracked the mystery of why cancer immunotherapy fails. “Unlike ordinary stress responses that slow protein production to help cells regain balance, TexPSR drives protein synthesis into overdrive. The result is a relentless buildup of misfolded proteins, stress granules, and toxic aggregates ¾ similar to the amyloid plaques seen in Alzheimer’s disease. This overload poisons the T cells, crippling their ability to attack tumors.”. Nature 01 Oct 2025.

How Trump Is Making China Great. Why we’re going to lose the trade war, and much more besides. by Paul Krugman

Pluralistic: Apple’s unlawful evil (06 Oct 2025) by Cory doctorow.
Apple has removed ICEBlock, a totally legal app that helps people track the movements of the masked snatch-squads who illegally terrorize brown people in America’s cities, capitulating to a warrantless demand from Trump’s DoJ boss Pam Bondi. link.

Scientists found that “young” immune cells made from human stem cells can reverse signs of aging and Alzheimer’s in mice. pub link.