Aging news

Senescent cells exhibit depletion of metabolites from nucleotide synthesis path- ways. Stable isotope tracing with 13C-labeled glucose or glutamine revealed a dramatic blockage of flux of these two metabolites into nucleotide synthesis pathways.  Blocking the pathway in replicative cells induces senescent phenotype.

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells. May28, 2019.  JBC. Alireza Delfarah, Sydney Parrish, Jason A. Junge, Jesse Yang, Frances Seo, Si Li, John Mac, Pin Wang, Scott E. Fraser, and X Nicholas A. Graham. DOI10.1074/jbc.RA118.005806. 

We report that naked mole-rat fibroblasts have significantly increased translational fidelity despite having comparable translation rates with mouse fibroblasts.
Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Azpurua J, Ke Z, Chen IX, Zhang Q, Ermolenko DN, Zhang ZD, Gorbunova V, Seluanov A. Proc Natl Acad Sci U S A. 2013 Sep 30.

Leave a Reply

Your email address will not be published. Required fields are marked *