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Yellow-throated Marten


Archive for May, 2015

TGF-β1 inhibitor stimulates stem cell division in old mice

Wednesday, May 20th, 2015

RepSox, a TGF-β1 inhibitor, promotes stem cell growth and enhances neurogenesis and muscle regeneration in old mice. Neurogenesis occurs primarily in the dentate gyrus of the hippocampus, and this is where the authors find it. No functional tests are shown.

The compound, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine or RepSox (PubChem) has been mentioned in half a dozen studies as a drug that promotes stem cell proliferation. Compound sells for research use at $50 / gram.

<p>Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Hanadie Yousef, Michael J. Conboy, Adam Morgenthaler, Christina Schlesinger, Lukasz Bugaj, Preeti Paliwal, Christopher Greer, Irina M. Conboy, David Schaffer
Oncotarget. May 06, 2015. (pdf)

Links for May 2015

Monday, May 11th, 2015

Analysis: Over Half of All Statements Made on Fox News Are False
Lokiarchaeota, an archea, is the closest relative to eukaryotes
Carl Zimmer on the biological mathematics of long bamboo flowering cycles (120 years!)
Paramagnetic fluid