Monthly Archive: April 2015

Fixing a Shark SV75 mini vaccum

Bad batteries–vaccum has 13 sub C NiCD cells. Tested voltage on the individual cells and replaced 6 bad cells.

The vaccum still wouldn’t charge–checking the charging circuit board showed a crack in a trace near the edge where the indicator LED is located. A bit of solder fixed it, and now it is charging.

FYI, the main IC on the circuit board is a ABOV MC96P0202, a 8-bit OTP CPU.

Average Number of Recessive Lethal Mutations Carried by Humans

Recently Gao et. al. published “An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans”. They studied a Hutterite group in South Dakota, highly inbred (63 founders 13 generations ago). From serious genetic diseases common in this population, they determine the number of deleterious variants present in the founders. They find that 0.29 recessive lethal alleles per haploid genome. Since some lethals manifest before birth, they double the estimate to 0.58.

This gives an expected 1.8% increased chance of a genetic disease from two first cousins.

Gao, Z., Waggoner, D., Stephens, M., Ober, C. & Przeworski, M. Genetics 199, 1243–1254 (2015).